The Institute for Regenerative Medicine and Biotherapy (IRMB) integrates INSERM (UMRS 1183), Université Montpellier I and the Hospital CHU de Montpellier. SAFE iPS is a cell reprogramming platform within the IRMB.

SAFE iPS develops within INGESTEM a bank of iPS cell lines of various diseases, particularly of premature aging.


  • Administrative Director: Dr. Jean-Marc Lemaitre
  • Scientific co-director: Prof. John de Vos, Dr. Jean-Marc Lemaitre
  • Technical manager: Dr. Romain Desprat


  • Genetic integrity of induced pluripotent stem cells
  • Study of normal and pathological aging/senescence.
  • Cell Therapy programs.

Involvement in INGESTEM:

  • Production of IPS cell lines of human pathologies
  • Generation of the IPS research bank
  • Genomic and functional characterization of iPS cell lines

Major publications:

  • Temporal analysis of genome alterations induced by single-cell passaging in human embryonic stem cells. Q Bai, Ramirez JM, Becker F, V Pantesco, Lavabre T-Bertrand, Hovatta O, Lemaître JM, Pellestor F, De Vos J. Stem Cells Dev. 1 March 2015; 24 (5): 653-62
  • MBNL1 and RBFOX2 Cooperate to ESTABLISH a splicing program Involved in pluripotent stem cell differentiation. Venables JP, Lapasset L, G Gadea, Fort P, R Klinck, Irimia M Vignal E, Thibault P, P Prinos, B Chabot, Abu Elela S, P Roux, JM Lemaitre, Tazi J.Nat Commun. 2013; 4: 2480
  • Embryonic stem cells or induced pluripotent stem cells? A DNA integrity perspective. Bai Q, R Desprat, Klein B, Lemaître JM, De Vos J. Curr Gene Ther. 2013 Apr; 13 (2): 93-8. Review.
  • Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Lapasset L, O Milhavet, Prieur A, E Besnard, Babled A, Ait Hamou N, J Leschik, Pellestor F, Ramirez JM, De Vos J, Lehmann S, JM Lemaitre. Genes Dev. 2011 Nov 1; 25 (21): 2248-53.
  • Brief report: Benchmarking human pluripotent stem cell markers During differentiation into the three germ layers unveils a striking heterogeneity: all markers are not equal. Ramirez JM, Gerbal Chaloin-S, O Milhavet, Qiang B, F Becker, Assou S, JM Lemaître, Hamamah S, De Vos J. Stem Cells. 2011 Sep; 29 (9): 1469-1474.

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