R&D Collaborations

iPS cell lines for animal models

INGESTEM offers expertise in the generation of induced pluripotent stem cell line (iPSC) in rabbits, pigs and non-human primates.

In order to complement the often inadequate mouse models, INGESTEM develops advanced research on these animal models through cell reprogramming to ensure:

  • production of somatic and germinal chimeras in different species (rabbit mouse, primates).
  • production of pluripotent stem cell lines that self-renew in the naive pluripotent state,
  • guaranteeing their potential to colonize the preimplantation embryo and contribute to the development of the fetus.
  • development of transgenic chimeric animals transgenic for disease modeling and improving the efficacy, safety and pharmacokinetics of therapeutics in preclinical development.
  • development of cell therapy and transplantation models (autologous or allogeneic) for preclinical validation of the therapeutic potential of iPS cells.
  • design of reporter systems for tracking and in vivo monitoring studies of engrafted cells


  • Rabbit
  • Cynomolgus macaque
  • Rhesus Macaque
  • Marmoset
  • Pig

Primary tissues

  • fibroblasts
  • mononuclear blood cells

Reprogramming methods

  • exclusively non-integrative (Sendai virus essentially)

Genetic modifications to the application:

  • CRISPR / Cas9
  • Lentiviral vector (SIV)
  • PiggyBac

For more information, please contact us.